Now that we are entering the last transition phase of COVID-19 in the United States where we are moving from an epidemic to endemic for the SARS-CoV-2 coronavirus, we need to focus on how safest to get there. Clearly, the introduction of a highly effective vaccine is abbreviating the time it would normally take to get our population immunity to this novel virus. What would have taken 2-5 years with multiple outbreaks throughout the country will now be less than 18 months before we get to a point where we no longer have massive spikes of cases, hospitalizations, and deaths from COVID-19.